Notice of Intent to Sole Source - Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB)

Project ID: 75N93024R00022 FederalOpportunitiesSpecial Notice

Overview

Agency	National Institutes of Health
Deadline	05/15/26
Posted	05/07/26
Estimated Value	Not Provided
Set Aside	None
NAICS	541714 - Research and Development in Biotechnology (except Nanobiotechnology)
PSC	AN12 - Health R&D Services; Health Care Services; Applied Research
Location	Rockville, MD 20852 United States

Description

Primary Latest Change

The aim of this solicitation is to continue the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) responsible for coordinating and conducting the design, synthesis, in vitro testing, and distribution of chemical libraries of discrete natural products and small-molecules with diverse physicochemical properties, specifically designed to target Gram-negative bacterial pathogens and other antibiotic-resistant bacteria identified as Antimicrobial Resistance threats. The contract shall consist of requirements in four (4) key areas: 1) Library Design, 2) Compound Synthesis, 3) Compound Testing, and 4) Compound Management, and includes Project Management of all efforts across these requirements. Any responsible offeror may submit a proposal which will be considered by the Agency. This RFP will be available electronically on April 08, 2026, and may be accessed through https://sam.gov/. Please note: After opening/downloading the solicitation in the Chrome browser, click the down arrow and select "Open with system viewer" to view the RFP in Adobe Acrobat. This process will allow the links in Section J of the RFP to work properly. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. For this solicitation, the NIAID requires proposals to be submitted online via the NIAID electronic Contract Proposal Submission (eCPS) website. Submission of proposals by facsimile or e-mail is not acceptable. For directions on using eCPS, go to the website https://ecps.nih.gov/ and then click on "How to Submit."

Summary (Newest Update)

Background The solicitation aims to continue the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB), which is responsible for coordinating and conducting the design, synthesis, in vitro testing, and distribution of chemical libraries targeting Gram-negative bacterial pathogens and other antibiotic-resistant bacteria identified as Antimicrobial Resistance threats. The National Institute of Allergy and Infectious Diseases (NIAID) issues this contract to enhance efforts against antibiotic resistance through innovative chemical solutions. Work Details The contract encompasses four key areas: 1) Library Design - generating new library ideas and developing them into Individual Library Production Plans (ILPPs); 2) Compound Synthesis - providing a breadth of small-molecule chemotypes, purification, analysis of intermediates and products; 3) Compound Testing - delivering Minimum Inhibitory Concentrations (MICs) for each product compound; 4) Compound Management - ensuring proper storage, handling, and distribution of chemical libraries. Additionally, project management will oversee all tasks across these requirements. Period of Performance The period of performance is expected to span from February 1, 2024, through January 31, 2035, with options for extension based on performance evaluations. Place of Performance The work will primarily be performed at the contractor's facilities capable of supporting high-throughput chemical synthesis and testing.

Contacts

Contact name	Ignacio Reyes, Contracting Officer
Contact email	ignacio.reyes@nih.gov
Contact phone	(301) 435-7574
Secondary contact name	Jonathan Bryan
Secondary contact email	jonathan.bryan@nih.gov
Secondary contact phone	(240) 669-5180